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FIGURE 5 | Brain-derived neurotrophic factor <t>(BDNF)</t> protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by <t>ELISA.</t> Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.
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FIGURE 5 | Brain-derived neurotrophic factor <t>(BDNF)</t> protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by <t>ELISA.</t> Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.
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FIGURE 5 | Brain-derived neurotrophic factor <t>(BDNF)</t> protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by <t>ELISA.</t> Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.
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FIGURE 5 | Brain-derived neurotrophic factor <t>(BDNF)</t> protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by <t>ELISA.</t> Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.
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FIGURE 5 | Brain-derived neurotrophic factor <t>(BDNF)</t> protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by <t>ELISA.</t> Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.
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FIGURE 5 | Brain-derived neurotrophic factor <t>(BDNF)</t> protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by <t>ELISA.</t> Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.
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Image Search Results


FIGURE 5 | Brain-derived neurotrophic factor (BDNF) protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by ELISA. Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.

Journal: Frontiers in psychiatry

Article Title: Quetiapine Attenuates Schizophrenia-Like Behaviors and Demyelination in a MK-801-Induced Mouse Model of Schizophrenia.

doi: 10.3389/fpsyt.2020.00843

Figure Lengend Snippet: FIGURE 5 | Brain-derived neurotrophic factor (BDNF) protein level in the frontal cortex of mice in control (Con), quetiapine (Que), MK-801 (MK), and MK-801+quetiapine (MK+Que) groups. Quetiapine attenuated the decrease of BDNF level in the frontal cortex of MK-801 mice. n=5 in each group. Mice were treated with chronic quetiapine (10 mg/kg/day, intraperitoneally) for 28 days. From day 22 to 28, 1 h after the administration of quetiapine, the mice were administered MK-801 (2 mg/kg/day, subcutaneously). One day after behavioral testing, the mice were sacrificed for BDNF protein analysis by ELISA. Results are expressed as means ± S.E.M. *P < 0.05 vs. Con, #P < 0.05 vs. MK.

Article Snippet: The level of BDNF was quantified using a commercial Mouse BDNF ELISA kit (Fitzgerald Industries International, North Acton, MA) according to the manufacturer’s protocol.

Techniques: Derivative Assay, Control, Enzyme-linked Immunosorbent Assay